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Lopirel Plus (30pcs Box)
Clopidogrel 75mg + Aspirin 75mg-
Acute Coronary Syndrome (ACS):
- Reduces the risk of Myocardial Infarction (MI) and Stroke in patients with:
- Non-ST-segment elevation ACS (Unstable Angina/NSTEMI).
- Acute ST-segment elevation ACS (STEMI).
Recent MI, Stroke, or Peripheral Arterial Disease:
- Reduces the risk of MI and Stroke in patients with a history of:
- Recent Myocardial Infarction (MI).
- Recent Stroke.
- Established Peripheral Arterial Disease.
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✅ Description:
Clopidogrel:
- A prodrug that inhibits platelet activation and aggregation.
- Irreversibly binds to the P2Y12 ADP receptor on platelets, preventing clot formation.
- Begins to inhibit platelet aggregation within 2 hours of administration.
- Steady-state inhibition is reached between Day 3 and Day 7.
Aspirin:
- Irreversibly inhibits cyclooxygenase (COX-1), preventing the production of thromboxane A2.
- Thromboxane A2 is responsible for platelet aggregation and vasoconstriction.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects: Lopirel Plus
Common:
- Increased bleeding risk.
- Bruising.
- Gastrointestinal discomfort.
Rare but Serious:
- Thrombotic Thrombocytopenic Purpura (TTP): Blood disorder causing clotting issues.
- Reye’s Syndrome: Risk in children with viral infections (flu, chickenpox).
✔️ Pharmacokinetics:
Absorption:
- Clopidogrel is rapidly absorbed with at least 50% bioavailability.
- Aspirin is well absorbed and reaches peak plasma levels within 30-40 minutes.
Metabolism & Elimination:
- Clopidogrel is metabolized primarily in the liver.
- 50% is excreted in urine, and 46% in feces within 5 days.
- Aspirin is hydrolyzed into salicylic acid and excreted by the kidneys.
✔️ Dosage & Administration: Lopirel Plus
- Standard Dose: Clopidogrel 75 mg once daily with or without food.
- Acute Coronary Syndrome:
- Loading dose: 300 mg Clopidogrel (one-time).
- Maintenance dose: 75 mg Clopidogrel daily + Aspirin (75-325 mg) daily.
✔️ Drug Interactions: Lopirel Plus
- Aspirin: Enhances the effect of Clopidogrel but increases the risk of bleeding.
- Heparin: No dose adjustment needed, but increased bleeding risk.
- NSAIDs: Increased risk of gastrointestinal bleeding.
- Warfarin: Increased risk of bleeding. Co-administration should be done with caution.
✔️ Contraindications:
- Hypersensitivity to Clopidogrel, Aspirin, or any component.
- Active bleeding disorders (e.g., Peptic Ulcer, Intracranial Hemorrhage).
✔️ Overdose Management: Lopirel Plus
Clopidogrel Overdose:
- Risk of severe bleeding – platelet transfusion may be required.
Aspirin Overdose:
- Symptoms: Dizziness, headache, tinnitus, confusion, nausea.
- Severe cases: Respiratory/metabolic acidosis, hyperthermia, dehydration.
- Treatment: Activated charcoal, gastric lavage, and hemodialysis if necessary.
✔️ Pregnancy & Lactation:
Pregnancy:
- 1st & 2nd trimesters: Use only if needed.
- 3rd trimester: Contraindicated due to bleeding risk.
Lactation:
- Clopidogrel: Unknown if excreted in human milk.
- Aspirin: Known to be excreted in breast milk – not recommended during breastfeeding.
✔️ Precautions & Warnings:
- May prolong bleeding time – use cautiously in patients with a bleeding risk.
- Monitor for signs of bleeding (black stools, unusual bruising).
- Avoid use in children <12 years due to the risk of Reye’s Syndrome.
✔️ Storage Conditions:
- Store below 30°C, in a cool & dry place, protected from light & moisture.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
